The conjugate linoleic acid occurs naturally in dairy products meat and safflower oil. Usually referred to by the initials of CLA the substance in particular promise to reduce body fat and increase muscle mass in humans <. h2> User
Supplements containing CLA claim the substance helps users lose weight in terms of fat and gain and maintain muscle. Ongoing and recently completed research projects listed on ClinicalTrials. gov website indicate CLA is also being studied as a therapy for asthma and allergies breast cancer diabetes arteriosclerosis (atherosclerosis) and thyroid disease.
There is no recommended daily intake of CLA exist. Total daily doses recommended by supplement manufacturers range from 1000 mg to 3900 mg per day usually taken in the form of a capsule or softgel per meal.
Evidence of Effectiveness
A review of clinical studies involving CLA published in the August 2006 issue of the journal Nutrition in Clinical Practice notes that CLA works well to prevent and alleviate atherosclerosis cancer diabetes and obesity in laboratory tests and animal experiments. By these actions the CLA role in reducing obesity has been the most well-documented in a human study.
Research reported in the Journal of Nutrition in May 2006 showed that daily supplementation with 6.4 grams of CLA for 12 weeks increased lean body mass of obese adults with 0.64 kg. On the other hand grants CLA of 3 grams / day in adults with type 2 diabetes for eight weeks had a negative effect on insulin and glucose metabolism according to researchers writing in the October 2004 American Journal of Clinical Nutrition.
The longest-term human trial of CLA that specifically looked at side effects found none of clinical concern. Writing in the October 2004 issue of Food and Chemical Toxicology researchers noted that people who were given 6 grams of supplemental CLA each day for one year showed no adverse effects in blood and organ function tests and even reported fewer side effects than study participants who received a placebo.
The National Library of Medicine’s online Dietary Supplements Labels Database presents CLA content ingredient dosage and manufacturer-provided label information for 17 brands CLA supplementation. The NLM site notes at the bottom of each product profile that the FDA has not evaluated any of the manufacturers’ requirements and that no supplements are “intended to diagnose treat cure or prevent any disease. Consult your healthcare professional before taking any dietary supplement.”
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