somatotropin is a protein-based peptide hormone secreted by the pituitary and is responsible for the growth of young animals in their adult size. in humans mediates the growth of children to their adult height and stimulates cells in many tissues. also called growth hormone (GH) it has also been used by athletes since at least 1970 to increase muscle mass and injury recovery speeds and has been promoted as an anti-aging drug.
when IGF -1 binds to cartilage cells these differentiate to create new bone. the higher the concentration of these hormones the more bone mass increases. thus the highest levels of both growth hormone and IGF -1 in the human body is reached during puberty growth spurt as much new bone is made. during their lifetime GH concentration gradually decreases and healthy adults will have levels less than two-thirds of those found in a young adolescent. GH has many effects on normal adult metabolism and they include promoting metabolism of fat new protein synthesis and production of glucose in the liver.
Somatotropin is secreted by the anterior pituitary which are made by cells called somatotrophs. these and all other pituitary cells respond to release of the precursor hormones of the hypothalamus by increasing or decreasing the amount of hormone they produce. hypothalamus sends precursor or releasing hormones” to the pituitary gland by separating them into their veins. precursor of growth hormone called somatotropin liberator hormone (SRH). the hypothalamus secretes SRH when the body needs more growth hormone in circulation.
various physiological conditions alert the hypothalamus to the need for more growth hormone production such as age nutrition gender physical activity and hormonal levels. even the time of day is important because more growth hormone is secreted during sleep than during waking somatotropin production is slowed or stopped when the hypothalamus releases the hormone somatostatin . an increase in the concentration of GH in the blood leads to the release of somatostatin by the hypothalamus which in turn causes the anterior pituitary to stop secreting GH.
a synthetic version of somatotropin called human growth hormone (HGH) or somatropin it is a recombinant protein produced using molecular biology technology. earlier growth hormone extracted from the pituitary gland of cadavers. somatropin used by some practitioners as an anabolic steroid to enhance athletic performance to help muscles recover more quickly from injury and to increase the proportion of muscle to fat there is no scientific consensus that HGH increases strength precisely. that promotes muscle growth.
HGH is used clinically to treat children who do not produce enough GH in their own bodies for normal growth. children who have Somatotropin deficiencies have usually short statures and often appear younger than they are. The disease can also delay the onset of puberty. HGH treatment reverses this condition.”